Chapter 13 - Signaling at the Cell Surface

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Biology

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13 Terms

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Second messengers
________ and kinase cascades help make signaling pathways more powerful.
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GPCR arrestin complex
________ initiates cytosolic kinases, and those cascades lead to the activation of cell growth controlling genes.
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CGMP synthesis
________ leads to protein kinase G being activated in vascular smooth muscle cells, which help with the muscles relaxation.
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PKA
________ has two effects on liver and muscle cells:
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Hormone
________ occupied receptors initiate the binding of GTP in the cell, causing Ga to interact with an effector protein.
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Light
________- activated ospin and the binding of arrestin to phosphorylated ospin activate transducin,
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Trimeric G
________ proteins convert into effector proteins, which help with either becoming another form of messengers or channel proteins in the cells.
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lipid rafts
When receptors and proteins cluster together, they form ________, which promote the interaction between signaling proteins and this enhances signal transduction.
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IP3
________ opens ________- gated Ca2+ channels in the endoplasmic reticulum.
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Ca2+ calmodulin complex
________ helps with the regulation of many different proteins:
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Kinase A
________ (PKA) can lead to phosphorylation of CREB protein, and with the CBP /300 coactivator, can cause the transcription of target genes.
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Nonprotein intracellular signaling molecules
________ help with the regulation of enzymatic and nonenzymatic proteins.
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PKA activation
________ is hormone- induced.