Lymphocyte Development

Entire δ

What is w.in α locus, so if α locus begins rearranging, T cell becomes α: β? Answer with a single words or term.

DiGeorge Syndrome

________: had underdeveloped /missing thymus as well as immune deficiency.

Clonal deletion

________: if B cells exhaust all possibilities for L- chain recombination, they are signaled to die by apoptosis in bone marrow.

Β chain rearrangements

________: can possibly happen more than once if they start w. downstream.

FDCs

________ provide signal for B cells to finish maturation.

Peripheral tolerance

________: render self- reactive T cells anergic.

Α chain

________ have a lot of V + J segments so they can rearrange many times for productive AND useful rearrangement.

Large pre B cell

________: successfully rearranged Heavy chain.

Small pre B cell

________: rearranging L chain; if κ fails, λ is rearranged.

IgM associates

________ w. Igα and Igβ to form B cell receptor complex 2nd checkpoint.

T cells

________ develop in thymus- Robert Good recognized that ppl w. thymus tumors had immunologic abnormalities.

Exit bone marrow

________ + move to 2nd lymphoid tissues.