T and B Cell Activation

IP3

________ increases cytosolic Ca2+ concentration, activating phosphatase Calcineurin, thus activating NFAT.

Macrophages

________ are anti- inflammatory, dont secrete inflammatory cytokines.

L Selectin

________ binds to CD34 + GlyCAM- 1, slowing T cell down.

Transcription factors

________ lead to the high- affinity α chain of IL- 2 receptor being expressed, along w. IL- 2.

CD45 tyrosine phosphatase

________ allows activation of receptor associated kinases.

Lck

________ phosphorylates ITAMs on cytoplasmic domains of CD3 + ζ chain.

CTL

________ releases cytotoxic granules w. perforin + granzymes onto target cell surface; perforins form channels for granzymes to enter target cell + induce proteases to cleave DNA + induce apoptosis.

Ag

________ is endocytosed, processed + presented on MHC.

Syk

________ binds to phosphorylated Igβ.

DAG

________ can activate Ras- induced signaling cascade, resulting in transcription factor AP- 1.

CR2

________: recognizes complement, soluble or cell surface Ag.