T and B Cell Activation
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11 Terms
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IP3
________ increases cytosolic Ca2+ concentration, activating phosphatase Calcineurin, thus activating NFAT.
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Macrophages
________ are anti- inflammatory, dont secrete inflammatory cytokines.
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L Selectin
________ binds to CD34 + GlyCAM- 1, slowing T cell down.
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Transcription factors
________ lead to the high- affinity α chain of IL- 2 receptor being expressed, along w. IL- 2.
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CD45 tyrosine phosphatase
________ allows activation of receptor associated kinases.
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Lck
________ phosphorylates ITAMs on cytoplasmic domains of CD3 + ζ chain.
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CTL
________ releases cytotoxic granules w. perforin + granzymes onto target cell surface; perforins form channels for granzymes to enter target cell + induce proteases to cleave DNA + induce apoptosis.
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Ag
________ is endocytosed, processed + presented on MHC.
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Syk
________ binds to phosphorylated Igβ.
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DAG
________ can activate Ras- induced signaling cascade, resulting in transcription factor AP- 1.
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CR2
________: recognizes complement, soluble or cell surface Ag.