Lymphocyte Development
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DiGeorge Syndrome
________: had underdeveloped /missing thymus as well as immune deficiency.
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Clonal deletion
________: if B cells exhaust all possibilities for L- chain recombination, they are signaled to die by apoptosis in bone marrow.
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FDCs
________ provide signal for B cells to finish maturation.
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Peripheral tolerance
________: render self- reactive T cells anergic.
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Α chain
________ have a lot of V + J segments so they can rearrange many times for productive AND useful rearrangement.
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IgM associates
________ w. Igα and Igβ to form B cell receptor complex 2nd checkpoint.
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