________ can be released through TGFB which releases a nuclear- localized signal after R- Smad moves out of the way.
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Ligands
________ trigger functional dimeric receptors and phosphorylation located in the lip in the kinases into a formation.
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Peptide sequences
________ with phosphotyrosine attach themselves to SH2 and PTB domains in signal- transducing proteins.
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transcription factors
The complex and ________ help with the expression of target genes.
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Proliferation
________ can be blocked due to TGFB signaling.
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RANKL
________ and RANK, its receptor, binding together results in bone resorption.
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dimeric growth factor
A(n) ________ can be released through mechanisms.
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Degradation
________ and ubiquitination of I- kB releases NF- kB which moves towards the nucleus.
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Adapter
________ protein GRB2 and Sos, associated with GEF activity, are both directly linked to RTKs.
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Ras
________ needs a guanine nucleotide exchange factor and GTPase activating protein for cycling.
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Erythropoietin
________ helps prevent down- regulation and elevated the number of blood cells.
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Dimerize
________ when binding with ligands.
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DNA techniques
________ can be produced by cell surface receptors and can be used as decoy receptors.
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JAK
________ protein tyrosine kinase and cytokine receptors are associated with each other and ________ protein tyrosine kinase can send stream signaling which helps with the activity of proteins and the transcription of certain genes.
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STAT
________ monomers and JAKs aid in the activation of transcription by dimerizing and moving towards the nucleus of the cell.
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TCF
________ and SRF promote the transcription of some early response genes.
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IP3 AG pathway
The ________ can be initiated by RTKs and Cytokine receptors.
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PI 3 phosphates
________ are bonded through the PH domain of proteins, which helps to form signaling complexes in the plasma membrane.
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NF kB
________ helps to regulate genes that tell cells to respond to infections and inflammation in the body.
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R Smad
________ binds to co- Smad, and that results in the created complex entering the nucleus.
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MAP kinase pathways
________ are found in yeast and higher eukaryotes and are triggered through the activation of receptors.
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Protein kinase B
________ needs PI 3- phosphates and PDK1 to fully activate.
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sensitivity of hormones
The ________ can be decreased through the number of receptor tyrosine kinases and cytokine receptors on the cell surface due to the receptor hormones degradation in lysosomes.
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Erythropoietin
________ helps to induce proliferation and differentiation of bone marrow erythroid progenitor cells, along with preventing apoptosis.
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Ras
________ is a type of GTPase protein that has similar downstream functions to RTKs.
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STAT
________ is phosphorylated by JAKs dimerize, move to the nucleus, and activate transcription.
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STAT
________ and JAK create a pathway that is downstream and comes into contact with all cytokine receptors.
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